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Chops, Prozac is included in the 'ineffective' group.I think the main problem with the tricyclics was their side effects (anticholinergic effects such as dry mouth, reduced perspiration, urinary retention, constipation, sedation), and that was largely why when the SSRI's became available many people changed. There was also the class of anti depressants called monoamine oxidase inhibitors which were pretty much a last resort because of potential toxic interactions with other drugs and foods such as cheese.It's a very interesting report and calls into question just how much the effectiveness of these antidepressants can in fact be attributed to the belief by patients that this drug is going to improve the way they feel.
Chops, Prozac is included in the 'ineffective' group.
I think the main problem with the tricyclics was their side effects (anticholinergic effects such as dry mouth, reduced perspiration, urinary retention, constipation, sedation), and that was largely why when the SSRI's became available many people changed.
There was also the class of anti depressants called monoamine oxidase inhibitors which were pretty much a last resort because of potential toxic interactions with other drugs and foods such as cheese.
It's a very interesting report and calls into question just how much the effectiveness of these antidepressants can in fact be attributed to the belief by patients that this drug is going to improve the way they feel.
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