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I always thought that depression was the body's reaction to chronic over production of adrenaline... that it reduced production of serotonin (sp?)to prevent 'blowing a fuse'... that negative thoughts/moods were the body's way of slowing one down, thus producing less adrenaline... less anxiety.

So it's actually one OR the other OR both...

It's interesting how slow breathing tricks the brain into thinking the body is relaxed and the heart beats slower. 

Then three minutes of slow breathing enables the liver to break down excess adrenaline... the goal of meditation... clearing the mind of clutter...